MEDICAL BIOTECHNOLOGY RESEARCH UNIT

The Medical Biotechnology Research Unit (MBU) was established in 1994 as the result of collaborative effort between the National Center for Genetic Engineering and Biotechnology (BIOTEC) and the Faculty of Medicine, Siriraj Hospital, Mahidol University. The objective of the unit is to maintain expertise in medical biotechnology research, with emphasis on dengue virus and dengue hemorrhagic fever as well as human genetic research. The unit consists of three affiliated laboratories located at the Faculty of Medicine Siriraj Hospital (Mahidol University), Department of Microbiology, Faculty of Medicine, and Department of Clinical Immunology, Faculty of Associated Medical Sciences (Chiang Mai University).

Research Activities

The unit maintains its focus of research on dengue virus and dengue hemorrhagic fever, human genetic diseases, and basic immunology. The research activities include:

1. Dengue research

• Pathogenesis of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS)
• The use and application of dengue infectious cDNA clones to study the molecular biology of dengue virus and generation of dengue vaccine candidates
• Development and application of dengue diagnostic technology including the application of new technologies and knowledge for better diagnosis and prevention of dengue virus infection

2. Genetics/genomics of prevalent diseases The application of genetic and genomic technologies to study a group of prevalent diseases in Thailand and development of technology for molecular diagnosis.

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Director
Prof. Dr. Prida Malasit

Key Researchers
Prof. Dr. Prida Malasit
Dr. Pa-thai Yenchitsomanus
Dr. Nopporn Sittisombut
Dr. Chunya Puttikhunt
Dr. Sansanee Noisakran