Commercial Chemicals from Natural Product Discovery

BIOTEC natural products research program searches for bioactive substances produced from various microorganisms, by using activity-guided fractionation and structure modification for increased biological activity. The focus has centered on insect pathogenic fungi as previous work has shown that they are an excellent source of chemical diversity, both in terms of structures and biological activities. This effort has resulted in a chemical library of pure compounds, chemical profile databases of crude extracts and a number of novel compounds published in international journals. These compounds can be further investigated for various industrial applications, such as in pharmaceutical and chemical industries.

BIOTEC has licensed the use of three microorganisms: Xylaria spp., Verticillium spp., and Lentinus spp. to Sigma Aldrich for commercial productions of depudecin, ascochlorin and panepoxydone, respectively.